Beyond apoptosis: nonapoptotic cell death in physiology and disease.

نویسندگان

  • Claudio A Hetz
  • Vicente Torres
  • Andrew F G Quest
چکیده

Apoptosis is a morphologically defined form of programmed cell death (PCD) that is mediated by the activation of members of the caspase family. Analysis of death-receptor signaling in lymphocytes has revealed that caspase-dependent signaling pathways are also linked to cell death by nonapoptotic mechanisms, indicating that apoptosis is not the only form of PCD. Under physiological and pathological conditions, cells demonstrate a high degree of flexibility in cell-death responses, as is reflected in the existence of a variety of mechanisms, including necrosis-like PCD, autophagy (or type II PCD), and accidental necrosis. In this review, we discuss recent data suggesting that canonical apoptotic pathways, including death-receptor signaling, control caspase-dependent and -independent cell-death pathways.

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عنوان ژورنال:
  • Biochemistry and cell biology = Biochimie et biologie cellulaire

دوره 83 5  شماره 

صفحات  -

تاریخ انتشار 2005